Dianne Frazier, PhD
(919) 966-9569 Main Office
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NBS Program Contact
Shortterm follow up
Primary Job Title
Metabolic dietitian and professor emeritus
Centers & Contact Information
Dianne Frazier, PhD, MPH, RD is a professor emeritus of pediatrics in the Division of Genetics and Metabolism at the University of North Carolina at Chapel Hill. Upon her retirement from the University in 2012, she was awarded the Order of the Long Leaf Pine by the Governor for her contributions to the people of NC. Dianne’s early training and doctorate were in biochemistry. Her first faculty appointment was in UNC’s Department of Biochemistry where one of her early assignments was to coordinate teaching of biochemistry in the Medical School. It was during that time that she began using a clinical approach (inborn errors of metabolism- IEM) to teach biochemical pathways. This became such a focus of hers that she earned her MPH in the UNC School of Public Health’s Department of Nutrition. After getting her RD, she began working with metabolic patients as well as teaching. Her laboratory work included developing techniques for newborn screening (NBS). She has been on the NC Newborn Screening Advisory Board for 33 years. Dianne has authored nine book chapters, published and presented scores of articles on inborn errors of metabolism, has taught, coordinated the follow-up for NC tandem mass spectrometry newborn screening, and followed metabolic patients at UNC. She has been active in the Southeastern Regional Genetic Group (SERGG) and participated in several federal initiatives dealing with IEM and NBS. She was a GMDI founding member, chair of the Research Committee (2006-09) and has held the offices of secretary, president elect and president of the GMDI Board (2009-12). Presently, she also chair of the working committee for the writing of nutrition guidelines for amino acidopathies and has recently led the team to complete the nutrition management guideline for MSUD.
Areas of Expertise
Newborn screening, inborn errors of metabolism
PhD (Biochemistry) Duke University, Durham, NC
MPH (Nutrition) UNC, Chapel Hill, NC
BA (Chemistry) Drew University, Madison, NJ
- Marquardt G et al. Enhanced interpretation of newborn screening results without analyte cutoff values. Genet Med. Advance online publication 2/16/2012.
- McHugh DM, el al. Clinical Validation of Cutoff Target Ranges in Newborn Screening of Metabolic Disorders by Tandem Mass Spectrometry: A Worldwide Collaborative Project. Genet Med. 2011 Mar; 13(3):230-54.
- Frazier DM, Tandem mass spectrometry newborn screening and its impact on inborn errors of metabolism. Topics in Clinical Nutrition, (2009) 24: 275-288.
Nutrition Management Guidelines Activity
2008 - Present